Gene description for TLN1
Gene name	talin 1
Gene symbol	TLN1
Other names/aliases	ILWEQ TLN talin-1
Species	Homo sapiens
Experiment description of studies that identified TLN1 in Glioblastoma cells
1 Experiment ID 722 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25802036    Organism Homo sapiens Experiment description Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. Authors de Vrij J, Maas SL, Kwappenberg KM, Schnoor R, Kleijn A, Dekker L, Luider TM, de Witte LD, Litjens M, van Strien ME, Hol EM, Kroonen J, Robe PA, Lamfers ML, Schilham MW, Broekman ML. Journal name Int J Cancer Publication year 2015 Sample Glioblastoma cells Sample name U87.MG/EGFRvIII Isolation/purification methods Differential centrifugation Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150064: EV-METRIC:0%, 0%, 29%
2 Experiment ID 1039 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name A172 Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
3 Experiment ID 1040 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name LN229 Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
4 Experiment ID 1041 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name U87MG Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK -
5 Experiment ID 1042 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name U251 Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
6 Experiment ID 1043 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name T98G Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
7 Experiment ID 1044 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 27770278    Organism Homo sapiens Experiment description Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Authors Mallawaaratchy DM, Hallal S, Russell B, Ly L, Ebrahimkhani S, Wei H, Christopherson RI, Buckland ME, Kaufman KL. Journal name J Neurooncol Publication year 2017 Sample Glioblastoma cells Sample name CCF-STTG1 Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.09.1.11 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
8 Experiment ID 1242 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25261722    Organism Homo sapiens Experiment description Inflammatory cytokines, interleukin-1 beta and tumor necrosis factor-alpha, upregulated in glioblastoma multiforme, raise the levels of CRYAB in exosomes secreted by U373 glioma cells. Authors Kore RA, Abraham EC. Journal name Biochem Biophys Res Commun. Publication year 2014 Sample Glioblastoma cells Sample name U373 cells treated with 10ng/ml of IL-1. Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry Western blotting EV-TRACK EV140183: EV-METRIC:22%
9 Experiment ID 1274 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Mass spectrometry PubMed ID 23807490    Organism Homo sapiens Experiment description Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. Authors Li CC, Eaton SA, Young PE, Lee M, Shuttleworth R, Humphreys DT, Grau GE, Combes V, Bebawy M, Gong J, Brammah S, Buckland ME, Suter CM. Journal name RNA Biol. Publication year 2013 Sample Glioblastoma cells Sample name U251 cells Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Mass spectrometry Microarray EV-TRACK EV130098: EV-METRIC:29%